Non-treated wastewater is used for irrigation of aquatic food production systems in the peri-urban areas of the major cities in Southeast Asia. This paper complement the knowledge on agricultural soil-based crops irrigated with low quality water, by reviewing the research findings on the wastewater-fed aquatic productions with special focus on heavy metals and other potentially toxic elements (PTEs) in the production systems of Hanoi in Vietnam and Phnom Penh in Cambodia.